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InaD-like protein

From Wikipedia, the free encyclopedia

PATJ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
External IDsOMIM: 603199; MGI: 1277960; HomoloGene: 72199; GeneCards: PATJ; OMA:PATJ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005799
NM_176877
NM_176878
NM_001350145

NM_001005784
NM_001005787
NM_007704
NM_172696
NM_001355177

RefSeq (protein)

NP_795352
NP_001337074

NP_001005784
NP_001005787
NP_031730
NP_766284
NP_001342106

Location (UCSC)Chr 1: 61.74 – 62.18 MbChr 4: 98.28 – 98.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

InaD-like protein is a protein that in humans is encoded by the PATJ gene.[5][6][7]

Function

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This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[7]

Interactions

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INADL has been shown to interact with MPP5.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132849Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061859Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290.
  6. ^ Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
  7. ^ a b "Entrez Gene: INADL InaD-like (Drosophila)".
  8. ^ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.

Further reading

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